BAR-501

Overview

BAR-501, a UDCA derivative, is a selective GPBAR1 agonist devoid of any FXR agonistic activity. BAR-501 effectively transactivates GPBAR1 in HEK293 cells overexpressing a CRE along with GPBAR1, with a EC50 of 1 μM. Besides, it protects against development of portal hypertension in rodent models of liver injury and endothelial dysfunction.

Application

Products > Drug Discovery > Impurities > Cardiovascular And Blood System > Bar-501 and Impurities | Products > Drug Discovery > Inhibitor

Product Information

• Catalog No.: B0084-482211
• CAS No.: 1632118-69-4
• Molecular Formula: C26H46O3
• Molecular Weight: 406.651
• Storage: Store in a cool and dry place and at 0 - 4°C for short term (days to weeks) or -42°C for long term (months to years).
• Solubility: Soluble in DMSO

Source

Original product source