Plecanatide

Overview

Plecanatide, also called Trulance, a synthetic analogue of uroguanylin, is a guanylate cyclase-C (GCC) agonist being developed by Synergy Pharmaceuticals for the treatment of gastrointestinal disorders, such as chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C). In January 2017, an oral formulation of plecanatide received its first global approval in the USA for the treatment of adult patients with CIC. Besides, Plecanatide is undergoing phase III investigation in IBS-C. It had also undergone preclinical investigations in inflammatory bowel disease (IBD) and ulcerative colitis; however, development in these indications has been discontinued. Sequence: NDEC(1)ELC(2)VNVAC(1)TGC(2)L Source summary: Plecanatide is a synthetic peptide used in the study of gastrointestinal tract functions and related biochemical processes. Explore our services and request a quotation today!

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Inflammation / Immunology | Guanylate Cyclase

Product Information

• Catalog No.: B0084-482218
• CAS No.: 467426-54-6
• Molecular Formula: C65H104N18O26S4
• Molecular Weight: 1681.89
• Storage: Store at -20°C
• Solubility: Soluble in water

Source

Original product source