BIO 5192

Overview

BIO 5192 is a selective and potent inhibitor of integrin α4β1 (Very Late Antigen-4; VLA-4) (Kd < 10 pM) with selectivity for α4β1 over a range of other integrins (IC50 values are 1.8, 138, 1053, > 500 and > 10,000 nM for α4β1, α9β1, α2β1, α4β7 and αIIbβ3, respectively). BIO 5192 causes a 30-fold increase in mobilization of murine hematopoietic stem and progenitors (HSPCs) over basal levels.

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Inflammation / Immunology | Integrin

Product Information

• Catalog No.: B2693-119144
• CAS No.: 327613-57-0
• Molecular Formula: C38H46Cl2N6O8S
• Molecular Weight: 817.78
• Purity: ≥98% by HPLC

Source

Original product source