CP-640186 is a potent inhibitor of mammalian ACCs and can reduce body weight and improve insulin sensitivity in test animals. It has recently been shown to be a potent inhibitor of isoforms of mammalian ACCs. Most importantly, CP-640186 can reduce body fat mass and body weight, and improve insulin sensitivity, validating ACCs as targets for antiobesity and antidiabetes drugs. Source summary: CP-640186 is a research-use small molecule for biochemical studies; explore its use as a chemical probe in inhibitor research.
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