Netupitant

Overview

Netupitant is a selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity. Netupitant competitively binds to and blocks the human substance P/NK1 receptors in the central nervous system (CNS), thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in the prevention of chemotherapy-induced nausea and vomiting (CINV). SP is found in neurons of vagal afferent fibers innervating the brain-stem nucleus tractus solitarii and the area postrema, which contains the chemoreceptor trigger zone (CTZ), and may be elevated in response to chemotherapy. The NK-receptor is a G-protein receptor coupled to the inositol phosphate signal-transduction pathway and is found in both the nucleus tractus solitarii and the area postrema. On 10/10 2014 FDA approved netupitant for the treatment of nausea and vomiting in patients undergoing cancer chemotherapy.

Application

Products > Drug Discovery > Impurities > Nervous System > Netupitant and Impurities | Products > Drug Discovery > Inhibitor

Product Information

• Catalog No.: B2693-465324
• CAS No.: 290297-26-6
• Molecular Formula: C30H32F6N4O
• Molecular Weight: 578.603
• Purity: >98%

Source

Original product source