(-)-Enitociclib (Standard)

Overview

(-)-Enitociclib (Standard) is the analytical standard of (-)-Enitociclib ( HY-103019B ). This product is intended for research and analytical applications. (-)-Enitociclib ((R)-Enitociclib) is an enantiomer of Enitociclib (HY-103019E) with an optical rotation of (-). Enitociclib is a selective CDK9 inhibitor and apoptosis inducer . Enitociclib inhibits CDK9 activity and reduces the phosphorylation of Ser2 in the carboxyl-terminal domain (CTD) of RNA polymerase Pol II, thereby downregulating the transcription of key oncogenes such as MYC and MCL1. Enitociclib has anti-proliferative activity targeting MYC+ lymphoma and multiple myeloma (MM) cells, and has synergistic effects with Bortezomib ( HY-10227 ) and Lenalidomide ( HY-A0003 ), and can be used in the research of hematological malignancies.

Application

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Product Information

• Catalog No.: HY-103019BR
• CAS No.: 1610408-96-2
• Molecular Formula: C19H18F2N4O2S
• Molecular Weight: 404.43
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source