CL-387785 (Standard)

Overview

CL-387785 (EKI-785; WAY-EKI 785) (Standard) is the analytical standard of CL-387785 ( HY-10325 ). This product is intended for research and analytical applications. CL-387785 is an orally active EGFR inhibitor with an IC 50 of 370 pM. CL-387785 inhibits EGF-stimulated EGFR autophosphorylation with an IC 50 of approximately 5 nM. CL-387,785 exerts selective inhibition on cell lines overexpressing EGFR or c-erbB-2, whereas it shows weak inhibitory effects on cell lines with low expression of these two receptors. CL-387785 effectively induces cell cycle arrest and apoptosis . CL-387785 can be used for the research of non-small cell lung cancer and autosomal recessive polycystic kidney disease.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Renal Disease | Products > Disease Areas > Polycystic Kidney Disease | Products > Disease Areas > Urogenital Disease | Products > Signaling Pathways > Others | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > JAK/STAT Signaling | Products > Research Areas > Endocrinology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Reference Standards | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > EGFR

Product Information

• Catalog No.: HY-10325R
• CAS No.: 194423-06-8
• Molecular Formula: C18H13BrN4O
• Molecular Weight: 381.23
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source