HKI-357 (Standard)

Overview

HKI-357 (Standard) is the analytical standard of HKI-357 ( HY-103443 ). This product is intended for research and analytical applications. HKI-357 is an irreversible dual inhibitor of EGFR and ERBB2 with IC 50 s of 34 nM and 33 nM, respectively. HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation.

Application

Products | Products > Signaling Pathways > Others | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Reference Standards | Products > Signaling Pathways > EGFR

Product Information

• Catalog No.: HY-103443R
• CAS No.: 848133-17-5
• Molecular Formula: C31H29ClFN5O3
• Molecular Weight: 574.05
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source