Pevonedistat hydrochloride (Standard)

Overview

Pevonedistat hydrochloride (Standard) is the analytical standard of Pevonedistat hydrochloride ( HY-10484 ). This product is intended for research and analytical applications. Pevonedistat (MLN4924) hydrochloride is a potent and selective NEDD8-activating enzyme (NAE) inhibitor, with an IC 50 of 4.7 nM. Pevonedistat hydrochloride induces the deregulation of S-phase DNA synthesis, thereby disrupting protein turnover mediated by cullin-RING ligase , leading to apoptosis of human tumor cells. Pevonedistat hydrochloride suppresses the growth of human tumour xenografts in mice.

Application

Products | Products > Signaling Pathways > Others | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Reference Standards | Products > Signaling Pathways > NEDD8-activating Enzyme | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-10484R
• CAS No.: 1160295-21-5
• Molecular Formula: C21H26ClN5O4S
• Molecular Weight: 479.98
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source