Etoprine is a potent orally active dihydrofolate reductase (DHFR) inhibitor. Etoprine competitively inhibits testicular DHFR to disrupt tetrahydrofolate and DNA synthesis in rapidly dividing cells . Etoprine acts as an antifertility agent in male mice and reduces fecundity in male rats.
Products | Products > Disease Areas > Urogenital Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Endocrinology | Products > Signaling Pathways > Dihydrofolate reductase (DHFR)
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