Iso-AS601245 TFA

Overview

Iso-AS601245 TFA is an orally active JNK inhibitor, with IC 50 values of 0.15 μM, 0.22 μM and 0.07 μM against JNK1 , JNK2 and JNK3 , respectively. Iso-AS601245 TFA reduces plasma TNF-α levels in mice and inhibits IL-2 secretion in activated T cells. Iso-AS601245 TFA alleviates adjuvant-induced rheumatoid arthritis in mice. Iso-AS601245 TFA can be used in studies related to rheumatoid arthritis.

Application

Products | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Arthritis | Products > Disease Areas > Rheumatoid Arthritis | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > JNK | Products > Signaling Pathways > TNF Receptor | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-10612A
• CAS No.: 1644386-60-6
• Molecular Formula: C24H18F6N6O4S
• Molecular Weight: 600.49
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source