RO 4938581 (Standard) is the analytical standard of RO 4938581 ( HY-107489 ). This product is intended for research and analytical applications. RO 4938581 is a potent and selective GABAA α5 inverse agonist, with a K i of 4.6 nM for GABAA α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (K i , 174, 185, 80 nM, respectively); RO 4938581 is used in the research of cognitive dysfunction.
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