Dynole 34-2 (Standard) is the analytical standard of Dynole 34-2 ( HY-107545 ). This product is intended for research and analytical applications. Dynole 34-2 is a potent dynamin GTPase inhibitor (IC 50 s=6.9 and 14.2 µM for dynamin1 and dynamin2 GTPase activity, respectively) with antimitotic effect. Dynole 34-2 induces apoptosis , as revealed by cell blebbing, DNA fragmentation, and PARP cleavage. Dynole 34-2 also potently inhibits receptor mediated endocytosis (RME).
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