SR 142948 (Standard)

Overview

SR 142948 (Standard) is the analytical standard of SR 142948 ( HY-107664 ). This product is intended for research and analytical applications. SR 142948 is an orally active and selective non-peptide neurotensin receptor (NT) antagonist with IC 50 s of 1.19 nM, 0.32 nM, 3.96 nM in h-NTR1-CHO cells, HT-29 cells, and adult rat brain, respectively. SR 142948 antagonizes NT-induced inositol monophosphate formation in HT-29 cells with an IC 50 of 3.9 nM. SR 142948 blocks hypothermia, analgesia and steering behavior induced by NT in vivo. SR 142948 shows blood-brain permeability and can be used in study of psychiatric disorders.

Application

Products | Products > Signaling Pathways > Others | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Reference Standards | Products > Signaling Pathways > Neurotensin Receptor

Product Information

• Catalog No.: HY-107664R
• CAS No.: 184162-64-9
• Molecular Formula: C39H51N5O6
• Molecular Weight: 685.85
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source