JK-P3 (Standard)

Overview

JK-P3 (Standard) is the analytical standard of JK-P3 ( HY-108933 ). This product is intended for research and analytical applications. JK-P3 is a potent and pan VEGFR2 inhibitor, with IC 50 s of 7.83 μM, 27 μM and 5.18 μM for VEGFR2, FGFR1 and FGFR3, respectively. JK-P3 can inhibit VEGF-A-stimulated VEGFR2 activation and intracellular signalling, also inhibits endothelial monolayer wound closure and angiogenesis, as well as fibroblast growth factor receptor K i nase activity in vitro. JK-P3 has anti-angiogenic activity.

Application

Products | Products > Signaling Pathways > Others | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Reference Standards | Products > Signaling Pathways > VEGFR | Products > Signaling Pathways > FGFR

Product Information

• Catalog No.: HY-108933R
• CAS No.: 942655-44-9
• Molecular Formula: C18H17N3O3
• Molecular Weight: 323.35
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source