Runcaciguat (Standard)

Overview

Runcaciguat (Standard) is the analytical standard of Runcaciguat ( HY-109136 ). This product is intended for research and analytical applications. Runcaciguat (BAY 1101042) is a selective, orally active, allosteric activator of soluble guanylate cyclase (sGC) that specifically targets its oxidized and heme-free form. Runcaciguat binds to sGC in a histidine-dependent manner and restores cyclic guanosine monophosphate (cGMP) production under oxidative stress, independent of nitric oxide (NO) or heme. Runcaciguat exhibits renoprotective and cardioprotective activities, such as reduced proteinuria and improved renal function. Runcaciguat is primarily being studied in chronic K i dney disease (CK d ) associated with hypertension, diabetes, and metabolic disorders, as well as potential cardiovascular indications such as heart failure with preserved ejection fraction (HFpEF).

Application

Products | Products > Signaling Pathways > Others | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Metabolic Disease | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Reference Standards | Products > Signaling Pathways > Guanylate Cyclase

Product Information

• Catalog No.: HY-109136R
• CAS No.: 1402936-61-1
• Molecular Formula: C23H22Cl2F3NO3
• Molecular Weight: 488.33
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source