PXS-4728A free base

Overview

PXS-4728A free base is an orally active, selective VAP-1/SSAO inhibitor with an IC 50 of 5 nM and a K i of 175 nM. PXS-4728A free base inhibits the expression of MMP-9 . It reduces cell rolling, adhesion and migration, decreases cell infiltration levels, pro-inflammatory cytokines, chemokines and collagen deposition, and improves pulmonary function. PXS-4728A free base reduces the formation and progression of atherosclerotic plaques, and decreases blood lipid and blood glucose levels as well as body weight gain. PXS-4728A free base can be used in research related to chronic obstructive pulmonary disease, cystic fibrosis, acute pulmonary inflammation, acute lung injury, bronchiolitis obliterans syndrome, rhinovirus-exacerbated asthma, sepsis, Klebsiella pneumoniae pulmonary infection and atherosclerosis.

Application

Products | Products > Disease Areas > Pulmonary Disease | Products > Disease Areas > Chronic Disease and Inflammation | Products > Disease Areas > Respiratory Inflammation | Products > Disease Areas > Lower Respiratory Inflammation | Products > Disease Areas > Viral Infection | Products > Disease Areas > Klebsiella Pneumoniae Infection | Products > Disease Areas > Chronic Obstructive Pulmonary Disease | Products > Disease Areas > Atherosclerosis and Inflammation | Products > Disease Areas > Bronchitis | Products > Disease Areas > Asthma | Products > Disease Areas > Acute Lung Injury | Products > Disease Areas > Cystic Fibrosis | Products > Disease Areas > Infection | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Bacterial Infection | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Infection | Products > Signaling Pathways > VAP-1 | Products > Signaling Pathways > MMP

Product Information

• Catalog No.: HY-112726A
• CAS No.: 1478364-40-7
• Molecular Formula: C15H21FN2O2
• Molecular Weight: 280.34
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source