PRMT/HKMT-IN-1

Overview

PRMT/HKMT-IN-1 is an epigenetic multi-target protein arginine methyltransferases ( PRMTs ) and histone lysine methyltransferases ( HKMTs ) inhibitor. PRMT/HKMT-IN-1 inhibits Aspergillus nidulans RmtA with an IC 50 of 29 μM. PRMT/HKMT-IN-1 inhibits human PRMT1 , p300/CBP HAT , CARM1 , SET7 , SIRT1 and SIRT2 . PRMT/HKMT-IN-1 inhibits methylation of histone H3K4 , H4R3 , and H3R17 residues. CBP/p300-IN-23 induces apoptosis , arrests cell cycle in S phase, and triggers granulocytic differentiation in leukemia cells. PRMT/HKMT-IN-1 can be used for the research of leukemia.

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Cancer | Products > Disease Areas > Fungal Infection | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Infection | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Fungal | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Discoidin Domain Receptor | Products > Signaling Pathways > Histone Acetyltransferase | Products > Signaling Pathways > Sirtuin

Product Information

• Catalog No.: HY-114510
• CAS No.: 1020399-52-3
• Molecular Formula: C19H12Br4O4
• Molecular Weight: 623.92
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source