LASSBio-1829 hydrochloride

Overview

LASSBio-1829 hydrochloride is an orally active IKK2 inhibitor with an IC 50 of 3.8 μM against the human target (Sf21 cells). LASSBio-1829 hydrochloride blocks signal transduction of the inflammation-associated NF-κB activation pathway. LASSBio-1829 hydrochloride reduces leukocyte migration, TNF-α biosynthesis, ROS production and NO production. LASSBio-1829 hydrochloride exhibits anti-inflammatory activity in a carrageenan-induced subcutaneous air pouch mouse model. LASSBio-1829 hydrochloride alleviates licking behavior during the inflammatory phase of the mouse formalin test. LASSBio-1829 hydrochloride can be used in inflammation-related research.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > IKK | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > TNF Receptor | Products > Signaling Pathways > Reactive Oxygen Species (ROS)

Product Information

• Catalog No.: HY-118973
• CAS No.: 1807810-16-7
• Molecular Formula: C25H19ClN4O
• Molecular Weight: 426.90
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source