Kolaflavanone

Overview

Kolaflavanone is an biflavonoid allosteric inhibitor of Eg5 . Kolaflavanone inhibits the ATPase and tyrosinase activities of Eg5 under both basal and microtubule-activated conditions, suppresses microtubule sliding activity, binds to the L5/α2/α3 allosteric pocket of Eg5, induces conformational changes of Eg5 and microtubule dissociation, interacts with aldehyde dehydrogenase , inhibits the ATPase activity of kinesin-1, and binds to HSA via pH-dependent forces . Kolaflavanone exhibits antihepatotoxic activity and can be used in studies related to Phalloidin ( HY-P0028 )-induced liver injury.

Application

Products | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Liver Disease | Products > Disease Areas > Liver Injury | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Cytoskeleton | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > Kinesin | Products > Signaling Pathways > Microtubule/Tubulin

Product Information

• Catalog No.: HY-121816
• CAS No.: 68705-66-8
• Molecular Formula: C31H24O12
• Molecular Weight: 588.52
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source