GK-136901

Overview

GK-136901 is an orally active, dual Nox1/Nox4 NADPH oxidase inhibitor with a K i of 160 nM for Nox1 and 165 nM for Nox4 . GK-136901 potently blocks high glucose-induced intracellular reactive oxygen species production, p38-MAPK phosphorylation, and upregulation of TGF-β1/2 and fibronectin ( fibronectin ) in renal cells. GK-136901 also inhibits the proliferation of mouse pulmonary vascular cells under hypoxic conditions. GK-136901 is applicable to the research on the pathogenesis of type 2 diabetic nephropathy, high glucose-related renal lesions and pulmonary hypertension.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Glucose Metabolism | Products > Disease Areas > Pulmonary Disease | Products > Disease Areas > Type 1 Diabetes | Products > Disease Areas > Pulmonary Hypertension | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > NADPH Oxidase | Products > Signaling Pathways > TGF-β Receptor | Products > Signaling Pathways > Reactive Oxygen Species (ROS)

Product Information

• Catalog No.: HY-124487
• CAS No.: 1062624-71-8
• Molecular Formula: C20H18N4O2
• Molecular Weight: 346.38
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source