ACT001 hydrochloride

Overview

ACT001 (Dimethylaminomicheliolide; DMAMCL) hydrochloride is an orally active, blood-brain barrier-permeable anti-inflammatory and anti-tumor agent. ACT001 hydrochloride exerts microglia-mediated neuroanti-inflammatory effects by inhibiting the AKT/NF-κB/NLRP3 axis and suppressing apoptosis ( apoptosis ). ACT001 hydrochloride inhibits tumor proliferation by upregulating NKTR and inhibiting AKT . ACT001 hydrochloride alleviates metabolic-associated fatty liver disease by regulating gut microbiota and inhibiting ileal FXR . ACT001 hydrochloride inhibits pyroptosis ( pyroptosis ) and pro-inflammatory cytokine release by activating PPAR-γ and inhibiting NF-κB/NLRP3 .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Respiratory Cancer | Products > Disease Areas > Pulmonary Disease | Products > Disease Areas > Respiratory Inflammation | Products > Disease Areas > CNS Infection | Products > Disease Areas > Digestive System Inflammation | Products > Disease Areas > Non-Small Cell Lung Cancer | Products > Disease Areas > Acute Lung Injury | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Vitamin D Related/Nuclear Receptor | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Akt | Products > Signaling Pathways > NOD-like Receptor (NLR) | Products > Signaling Pathways > PPAR | Products > Signaling Pathways > FXR | Products > Signaling Pathways > Pyroptosis

Product Information

• Catalog No.: HY-128861B
• CAS No.: 1403357-80-1
• Molecular Formula: C17H28ClNO3
• Molecular Weight: 329.86
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source