G6PD-IN-2 is a Plasmodium falciparum glucose-6-phosphate dehydrogenase ( G6PD ) inhibitor with an IC 50 value of 0.2 μM. G6PD-IN-2 exerts weak inhibitory activity on Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase ( PfGluPho ) with an IC 50 value of 22.0 μM. G6PD-IN-2 inhibits growth of Plasmodium falciparum 3D7 strain and exhibits low cytotoxicity in hepatocytes. G6PD-IN-2 can be used for the research of malaria.
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