AMG 369 is an orally active and potent dual S1P 1 /S1P 5 agonist with limited activity at S1P 3 and no activity at S1P 2 /S1P 4 . AMG 369 reduces blood lymphocyte counts. AMG 369 delays onset and reduces severity of experimental autoimmune encephalomyelitis in rat.
Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > CNS Infection | Products > Disease Areas > Experimental Autoimmune Encephalomyelitis | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Infection | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > LPL Receptor
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