cGAS-IN-9

Overview

cGAS-IN-9 is a cyclic guanosine monophosphate-adenosine monophosphate synthase ( cGAS ) inhibitor, with IC 50 values of 27.5 nM and 5.15 μM against human and murine cGAS, respectively. cGAS-IN-9 shows weak inhibitory activity against human soluble adenylate cyclase , with an IC 50 of 26.4 μM. cGAS-IN-9 inhibits dsDNA-induced expression of IFNB1 and CXCL10 , as well as activation of the NF-κB pathway, in human immune cells. cGAS-IN-9 can be used in research related to cGAS-dependent inflammatory diseases.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Guanylate Cyclase | Products > Signaling Pathways > Adenylate Cyclase | Products > Signaling Pathways > CXCR | Products > Signaling Pathways > NF-κB

Product Information

• Catalog No.: HY-147129
• CAS No.: 2369750-66-1
• Molecular Formula: C16H14Cl2N4O2
• Molecular Weight: 365.21
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source