2-(tert-butyldiMethylsilyl )oxyl alcohol trifluorin Methanesulfonate

CAS No.：164162-36-1

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2-(tert-butyldiMethylsilyl )oxyl alcohol trifluorin Methanesulfonate Basic information

Product Name:	2-(tert-butyldiMethylsilyl )oxyl alcohol trifluorin Methanesulfonate
Synonyms:	2-{[Dimethyl(2-methyl-2-propanyl)silyl]oxy}ethyl trifluoromethanesulfonate;Trifluoromethanesulfonic acid 2-[[(tert-butyl)dimethylsilyl]oxy]ethyl ester;2-(t-ButyldiMethylsilyl)oxyethyl triflate;Methanesulfonicacid,1,1,1-trifluoro-,2-[[(1,1-diMethylethyl)diMethylsilyl]oxy]ethylester;2-(t-Butyldimethylsilyloxy)EthylTrifluoromethanesulfonate;2-(tert-butyldiMethylsilyl )oxyl alcohol trifluorin Methanesulfonate;2-(tert-butyldiMethylsilyloxy)ethyl trifluoroMethanesulfonate;1,1,1-Trifluoromethanesulfonic acid 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl ester
CAS:	164162-36-1
MF:	C9H19F3O4SSi
MW:	308.39
EINECS:
Product Categories:
Mol File:	164162-36-1.mol

2-(tert-butyldiMethylsilyl )oxyl alcohol trifluorin Methanesulfonate Chemical Properties

Boiling point	253℃
density	1.172
Fp	107℃

Safety Information

MSDS Information

2-(tert-butyldiMethylsilyl )oxyl alcohol trifluorin Methanesulfonate Usage And Synthesis

Uses

2-(tert-butyldiMethylsilyl )oxyl alcohol trifluorin Methanesulfonate is used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis

The reaction was carried out under a nitrogen atmosphere. TBS- ethylene glycol prepared as per step 1 (85.10g, 0.48 mol) and 2, 6-Lutidine (84.28ml, 0.72 mol) were stirred in n-heptane (425ml) to give a clear solution which was then cooled to -15 to - 25°C. Trifluoromethanesulfonic anhydride (Tf2O) (99.74 ml, 0.590 mol) was added drop-wise over a period of 45 minutes to the n-heptane solution (white precipitate starts to form immediately) while maintaining the reaction at -15 to -25°C. The reaction mixture was kept at temperature between -15 to -25°C for 2 hours. The precipitate generated was filtered off. The filtrate was then evaporated up to ~2 volumes with respect to TBS-ethyiene glycol (~200 ml).

2-(tert-butyldiMethylsilyl )oxyl alcohol trifluorin Methanesulfonate Preparation Products And Raw materials

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