8-(4-Chlorophenylthio)-cAMP

Overview

8-(4-Chlorophenylthio)-cAMP (8CPT-cAMP) is a cell membrane-permeable cAMP analog with excellent membrane permeability, which activates Sgk kinase via phosphorylation mediated by PKA . 8-(4-Chlorophenylthio)-cAMP is hydrolyzed by intracellular enzymes to produce the active metabolite 8CPT-Ade, which induces cortisol synthesis and the expression of steroidogenic protein genes. When used in combination with insulin , 8-(4-Chlorophenylthio)-cAMP enhances the activation of Sgk ; it activates the cAMP pathway to promote the proliferation and iodine uptake of thyroid cells. 8-(4-Chlorophenylthio)-cAMP can be used in studies related to metabolism and signal transduction.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > SGK | Products > Signaling Pathways > PKA

Product Information

• Catalog No.: HY-155940
• CAS No.: 41941-66-6
• Molecular Formula: C16H15ClN5O6PS
• Molecular Weight: 471.81
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source