AFP464

Overview

AFP464 (NSC710464) is a prodrug of Aminoflavone ( HY-132974 ) and an agonist of the aryl hydrocarbon receptor ( AhR ). AFP464 downregulates the expression of α6-integrin ( α6-integrin ), inhibits breast tumor growth, reduces the population of tumor-initiating cells, disrupts mammosphere structure, induces the formation of mucin lake clusters, triggers DNA damage, and exerts antiproliferative activity. AFP464 is rapidly converted to Aminoflavone by nonspecific esterases in plasma and cell culture media. AFP464 is applicable to research related to breast cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Breast Cancer | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Cytoskeleton | Products > Signaling Pathways > Others | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Aryl Hydrocarbon Receptor | Products > Signaling Pathways > Integrin | Products > Signaling Pathways > Drug Intermediate | Products > Signaling Pathways > DNA/RNA Synthesis

Product Information

• Catalog No.: HY-16031A
• CAS No.: 468719-53-1
• Molecular Formula: C24H31F3N4O9S2
• Molecular Weight: 640.65
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source