(+)-Decanoylcarnitine

Overview

(+)-Decanoylcarnitine is an (S)-acylcarnitine derivative and a potent inhibitor of carnitine-acylcarnitine translocase, with an IC 50 of 5 μM. (+)-Decanoylcarnitine acts as a competitive inhibitor of long-chain acylcarnitine transferase and (-)-carnitine palmityltransferase . (+)-Decanoylcarnitine blocks hepatic fatty acid oxidation, ketogenesis, oleate-induced activation of gluconeogenesis, as well as associated changes in acetyl-CoA, citrate, redox pair ratios, flavins and pyridine nucleotides. (+)-Decanoylcarnitine reverses ketosis in vivo, enhances insulin-mediated hypoglycemic effects in anesthetized animals , and reduces plasma ketone body levels when used in combination with insulin . (+)-Decanoylcarnitine can be used in studies related to diabetic ketoacidosis.

Application

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Product Information

• Catalog No.: HY-165175
• CAS No.: 25518-51-8
• Molecular Formula: C17H33NO4
• Molecular Weight: 315.45
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source