BMS-986331

Overview

BMS-986331 is an orally active selective N-Formyl Peptide Receptor 2 (FPR2) agonist with an EC 50 of 0.5 nM in humans and 1 nM in rats. BMS-986331 activates Gαi2 , GαoA , Gα12 , Gα13 signaling pathways, recruits β-arrestin1 and β-arrestin2 , and inhibits downstream cAMP . BMS-986331 induces the expression and release of the pro-resolution cytokine IL-10 . BMS-986331 improves cardiac structure and function in a rat model of heart failure induced by permanent coronary artery occlusion. BMS-986331 can be used for the research of heart failure.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Cardiovascular Disease | Products > Disease Areas > Heart Disease | Products > Disease Areas > Heart Failure | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Formyl Peptide Receptor (FPR) | Products > Signaling Pathways > Arrestin | Products > Signaling Pathways > PKA | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-181822
• CAS No.: 2375684-52-7
• Molecular Formula: C25H22ClF3N3O3P
• Molecular Weight: 535.88
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source