Lenalidomide-CO-C7-NH2

Overview

Lenalidomide -CO-C7-NH2 is a CRBN -dependent intermediate of BET PROTAC degrader. Consisting of the E3 ubiquitin ligase ligand Lenalidomide ( HY-A0003 ) conjugated with a PROTAC linker , Lenalidomide -CO-C7-NH2 induces the protein degradation. By depleting BRD4, PROTAC BET Degrader-16 effectively inhibits cancer cell proliferation, induces cell cycle arrest and promotes apoptosis , thereby exhibiting significant anti-tumor activity in xenograft models. Lenalidomide -CO-C7-NH2 serves as an important tool molecule for the study of acute myeloid leukemia.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Acute Myeloid Leukemia | Products > Signaling Pathways > PROTAC | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer | Products > Signaling Pathways > E3 Ligase Ligand-Linker Conjugates

Product Information

• Catalog No.: HY-181868
• CAS No.: 1957236-16-6
• Molecular Formula: C21H28N4O4
• Molecular Weight: 400.47
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source