Nrf2 activator-23

Overview

Nrf2 activator-23 is an orally active Keap1 binder and Nrf2 activator, with K D values of 28.68 nM and 54.55 nM for Keap1 and its Kelch domain, respectively. Nrf2 activator-23 disrupts the Keap1 - Nrf2 interaction, reduces ubiquitination and degradation of Nrf2 , and activates the Nrf2 signaling pathway. Nrf2 activator-23 inhibits RANKL -induced osteoclast formation, bone resorptive activity, ROS production, and activation of the MAPK and NF-κB signaling pathways, while downregulating the expression of osteoclast-specific genes and proteins. Nrf2 activator-23 attenuates bone loss and reduces osteoclast formation in vivo without affecting osteoblast differentiation and mineralization. Nrf2 activator-23 can be used for the research of osteoporosis.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Mineral Metabolism | Products > Disease Areas > Osteoporosis | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > Keap1-Nrf2 | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > p38 MAPK

Product Information

• Catalog No.: HY-181887
• CAS No.: 3109883-60-2
• Molecular Formula: C23H17FO2Se
• Molecular Weight: 423.34
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source