Antibiotic adjuvant 4 (Compound 13) is an Antibiotic adjuvant and efflux pump inhibitor. Antibiotic adjuvant 4 exhibits potent efflux pump inhibitory activity. Antibiotic adjuvant 4 significantly downregulates virulence-related genes of Staphylococcus aureus when used alone or in combination with antibiotics . Antibiotic adjuvant 4 enhances the efficacy of Ciprofloxacin ( HY-B0356 ) against multiagent-resistant Staphylococcus aureus strains.
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