VPC285785 is an orally active SARS-CoV-2 main protease inhibitor with an IC 50 of 0.8 μM and a K d of 2.7 μM. VPC285785 functionally inhibits the viral main protease-mediated processing of viral polyprotein precursors required for viral replication. VPC285785 reduces viral loads in the liver, brain and spleen tissues of MHV-infected mice. VPC285785 is applicable to the research of coronavirus infections.
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