PDE4B/D-IN-5

Overview

PDE4B/D-IN-5 (Compound P32) is a peripherally restricted, oral active inhibitor of PDE4B and PDE4D with extremely low blood-brain barrier penetration, with IC 50 values of 3.4 nM and 2.2 nM, respectively. PDE4B-IN-8 inhibits the production of TNF-α . PDE4B/D-IN-5 significantly reduces the Bax / Bcl2 ratio, and alleviates oxidative stress by decreasing MPO activity and NO levels. PDE4B/D-IN-5 exhibits anti-inflammatory, antioxidant, and anti-apoptotic activities. PDE4B/D-IN-5 can be used for the research of acute lung injury.

Application

Products | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Pulmonary Disease | Products > Disease Areas > Respiratory Inflammation | Products > Disease Areas > Acute Lung Injury | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Phosphodiesterase (PDE) | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > NO Synthase | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-182060
• CAS No.: 3064814-26-9
• Molecular Formula: C22H21F2N5O2
• Molecular Weight: 425.43
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source