ZAK-IN-2

Overview

ZAK-IN-2 (Compound 8) is a selective, covalent ZAK inhibitor with an IC 50 of 11.5 nM. ZAK-IN-2 forms a covalent bond with Cys22 in the P-loop of ZAK to inhibit its kinase activity. ZAK-IN-2 inhibits the phosphorylation of the downstream target p38 . ZAK-IN-2 blocks Doxorubicin ( HY-15142A )-induced cleavage of Caspase 3 . ZAK-IN-2 is applicable to research related to myocardial hypertrophy.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Heart Disease | Products > Disease Areas > Cardiomyopathy | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > MAP3K | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > p38 MAPK

Product Information

• Catalog No.: HY-182103
• CAS No.: 3033697-19-4
• Molecular Formula: C33H26F2N8O4S
• Molecular Weight: 668.67
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source