Other grades of this product :
| noxytiolin Basic information |
| Product Name: | noxytiolin | | Synonyms: | noxytiolin;Noxythiolin;1-(Hydroxymethyl)-3-methylthiourea;Gynaflex;Noxyflex S;Noxytioline;(methylamino-λsup4sup-sulfanylidyne)methylamino]methanol;Noxythioline | | CAS: | 15599-39-0 | | MF: | C3H8N2OS | | MW: | 120.17 | | EINECS: | 2396795 | | Product Categories: | | Mol File: | 15599-39-0.mol |
| noxytiolin Chemical Properties |
| Melting point | 88-90° | | Boiling point | 203.7±42.0 °C(Predicted) | | density | 1.223±0.06 g/cm3(Predicted) | | pka | 13.45±0.10(Predicted) |
| Toxicity | LD50 orally in mice: >3 g/kg (Aebi, Hafstetter) |
| noxytiolin Usage And Synthesis |
| Originator | Noxyflex,Geistlich,UK,1964 | | Manufacturing Process | 400 g methyl thiourea and 2.5 g NaHCO3 are dissolved in 400 ml formaldehyde solution of 35% concentration. After having been left at ordinary temperature for 2 to 3 hours, the solution is adjusted with dilute HCl to pH 7 to 7.5. After the reaction mixture had been left overnight at 15°C some of the final product crystallized and was filtered off using a Buchner funnel. The mother liquor was concentrated by evaporation in vacuo at a bath-temperature of 30°C. The crystals obtained were again collected by filtration using a Buchner funnel and were combined with the first crystalline fraction and dried in vacuo at ordinary temperature. Yield of pure substance 400 g; melting point 84°C to 86°C.
| | Therapeutic Function | Antifungal |
| noxytiolin Preparation Products And Raw materials |
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