FXR DUBTAC modulator-1

Overview

FXR DUBTAC modulator-1 is a deubiquitinase-targeting chimeric molecule ( DUBTAC ) that targets FXR , with a K a value of 2.12e-5 M for FXR . FXR DUBTAC modulator-1 recruits the deubiquitinase OTUB1 , binds to OTUB1 and forms a ternary complex with FXR , reduces the polyubiquitination level of FXR , prevents FXR degradation via the ubiquitin-proteasome pathway, and elevates the protein level of FXR . FXR DUBTAC modulator-1 can be used in the research of cholestatic liver injury.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Lipid Metabolism | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > DUBTACs | Products > Signaling Pathways > FXR

Product Information

• Catalog No.: HY-182350
• CAS No.: 3081876-96-9
• Molecular Formula: C43H66N4O7
• Molecular Weight: 751.01
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source