ODZ10117

Overview

ODZ10117 is a STAT3 and NLRP3 inhibitor with a human STAT3 SH2 domain IC 50 of 7.5 μM. ODZ10117 binds to the STAT3 SH2 domain, suppressing tyrosine phosphorylation, dimerization, nuclear translocation, and transcriptional activity. ODZ10117 binds to NLRP3 , impairs NEK7 interaction, prevents inflammasome formation, and inhibits caspase-1 and IL-1β cleavage.ODZ10117 reduces MSU ( HY-B2130A )-induced IL-1β release, lowers LPS ( HY-D1056 )-induced sepsis mortality, and exhibits anti-inflammatory effects. ODZ10117 induces apoptosis , suppresses breast cancer cell migration and invasion, reduces tumor growth and lung metastasis, and extends survival in breast cancer models. ODZ10117 can be used for the research of Monosodium urate ( HY-B2130A )-induced peritonitis, LPS-induced sepsis, breast cancer , glioblastoma, and Alzheimer's disease.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Others | Products > Disease Areas > CNS Neoplasm | Products > Disease Areas > Glioma | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Pathogens Infection | Products > Disease Areas > Digestive System Inflammation | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Glioblastoma | Products > Disease Areas > Alzheimer's Disease | Products > Disease Areas > Peritonitis | Products > Disease Areas > Nonalcoholic Steatohepatitis | Products > Disease Areas > Cancer | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Others | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > STAT | Products > Signaling Pathways > NOD-like Receptor (NLR) | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-182380
• CAS No.: 1632152-27-2
• Molecular Formula: C10H5Cl5N2O2
• Molecular Weight: 362.42
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source