BPN-14136

Overview

BPN-14136 is an orally effective retinol-binding protein 4 (RBP4) inhibitor. BPN-14136 inhibits the binding of retinol to RBP4 with an IC 50 of 12.8 nM. BPN-14136 inhibits retinol-dependent RBP4-transthyretin interaction ( IC 50 = 43.6 nM) and reduces circulating plasma RBP4 levels in vivo. BPN-14136 decreases the formation of cytotoxic bisretinoids in retinal pigment epithelial cells. BPN-14136 can be used for the research of atrophic age-related macular degeneration and Stargardt disease.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > Lipocalin Family

Product Information

• Catalog No.: HY-182385
• CAS No.: 1628945-93-6
• Molecular Formula: C20H20F3N3O2
• Molecular Weight: 391.39
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source