UAWJ248 is a SARS-CoV-2 main protease (M pro ) inhibitor with an IC 50 of 0.012 μM. UAWJ248 inhibits activity via initial reversible binding followed by irreversible inactivation. UAWJ248 inhibits SARS-CoV-2 replication and can be used for the research of SARS-CoV-2 infection .
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