DABMA

Overview

DABMA is a TMEM175 channel activator with a human EC 50 of 17.9 μM. DABMA directly increases TMEM175 channel current via interaction with intracellular, transmembrane, or endosomal lumen-associated domains, and does not alter TMEM175 mRNA or protein levels. DABMA delays endolysosomal substrate degradation, modulates endolysosomal trafficking, increases acidic organelle accumulation, induces cholesterol accumulation and altered late endosome morphology. DABMA can be used for the research of coronavirus disease, Clostridium difficile infection , Pseudomonas aeruginosa infection , rabies, and influenza virus infection.

Application

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Product Information

• Catalog No.: HY-182464
• CAS No.: 893603-33-3
• Molecular Formula: C20H28BrNO
• Molecular Weight: 378.35
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source