ONO-8539

Overview

ONO-8539 is an orally active prostanoid EP1 receptor antagonist with competitive, insurmountable binding and slow receptor dissociation for long-duration inhibition. ONO-8539 modulates afferent nerve function related to bladder activity, inhibits detrusor overactivity-related contractions, decreases nonvoiding contractions and voiding duration, and increases uroflow rate with ATP ( HY-B2176 )-induced detrusor overactivity. ONO-8539 attenuates acid-induced heartburn symptoms, extends time to first heartburn sensation, and prevents primary hypersensitivity after distal esophageal acidification. ONO-8539 can be used for the research of overactive bladder and gastroesophageal reflux disease.

Application

Products | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Others | Products > Disease Areas > Gastric Disease | Products > Disease Areas > Gastroesophageal Reflux Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Others | Products > Signaling Pathways > Prostaglandin Receptor

Product Information

• Catalog No.: HY-182513
• CAS No.: 459842-29-6
• Molecular Formula: C25H28N2O5S2
• Molecular Weight: 500.63
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source