LN5972 is a selective ACKR3 agonist with an EC 50 of 3.40 μM, showing higher selectivity for ACKR3 over CXCR4 . LN5972 induces β-arrestin recruitment to ACKR3/CXCR7 . LN5972 reduces the surface expression of P-selectin . LN5972 is applicable to studies related to platelet-mediated thrombosis.
Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Blood Disease | Products > Disease Areas > Platelet Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > CXCR
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