Nandinine is an orally active derivative of Berberine ( HY-N0716 ). Nandinine enhances AMPK activity, inhibits the activation of IKKβ/NF-κB , and regulates the phosphorylation of IRS-1 . Nandinine reverses the abnormal production of adipokines, promotes insulin-mediated glucose uptake, and alleviates insulin resistance. Nandinine improves glucose tolerance and increases the insulin sensitivity index in mice. Nandinine can be used in studies related to insulin resistance.
Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Glucose Metabolism | Products > Signaling Pathways > Others | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > NF-κB | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > Drug Derivative | Products > Signaling Pathways > AMPK | Products > Signaling Pathways > IKK | Products > Signaling Pathways > NF-κB
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