ITI-367 is a HIV-1 inhibitor that targets the nuclear localization signal 1 ( NLS-1 ) of HIV-1 matrix protein and the interaction between HIV-1 pre-integration complex ( PIC ) and importin-β . ITI-367 inhibits HIV-1 replication at the pre-integration stage, reduces the formation of 2-LTR circles, and sequesters viral DNA in the cytoplasm. ITI-367 can be used for the research of HIV infection .
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