RWJ-58259

Overview

RWJ-58259 is a selective PAR-1 inhibitor with an IC 50 value of 0.15 μM. RWJ-58259 binds selectively to PAR-1 , blocks the binding of tethered ligands, interferes with calcium mobilization and PAR-1 -related cellular functions, and exhibits no PAR-1 agonist activity or thrombin proteolytic inhibitory activity. RWJ-58259 inhibits thrombin-induced platelet aggregation, calcium signaling and vascular smooth muscle cell proliferation, reduces neointimal thickness and arterial stenosis, and alleviates vascular occlusion and platelet deposition. RWJ-58259 can be used in the research of thrombotic diseases and vascular injury associated with acute coronary intervention.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Blood Disease | Products > Disease Areas > Cardiovascular Disease | Products > Disease Areas > Platelet Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Protease Activated Receptor (PAR)

Product Information

• Catalog No.: HY-182573
• CAS No.: 315203-31-7
• Molecular Formula: C40H42Cl2F2N8O3
• Molecular Weight: 791.72
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source