Decyl gallate is an antifungal ( fungal ) agent. Decyl gallate downregulates the expression of the pro-apoptotic ( apoptosis ) protein Bak , upregulates the expression of the anti-apoptotic protein Bcl-2 , and inhibits DNA damage. Decyl gallate disrupts ALG12 -mediated N-glycosylation, overactivates the UPR pathway, and simultaneously reduces fungal cell wall enzyme activity, chitin levels, mitochondrial activity, budding ability, cell viability, and host cell adhesion capacity. Decyl gallate reduces inflammatory responses induced by fungal infection and disrupts fungal membrane structure. Decyl gallate can be used in studies related to paracoccidioidomycosis and invasive fungal infections.
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