LP-935001 is a Notum carboxylesterase inhibitor with an IC 50 of 0.4 nM.LP-935001 prevents palmitoleate group removal from Wnt proteins, restores Wnt/β-catenin signaling.LP-935001 enhances cortical bone thickness in rodent models.LP-935001 can be used for the research of bone loss/nonvertebral fractures.
Products | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Carboxylesterase (CES) | Products > Signaling Pathways > Wnt | Products > Signaling Pathways > β-catenin
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