ACT-774312 is a potent and selective CRTH2 antagonist with an IC 50 of 4 nM. ACT-774312 blocks the activity and internalization of the CRTH2 receptor, and inhibits PGD 2 -induced morphological changes in eosinophils. ACT-774312 can be used in the research of nasal polyps and type 2 inflammatory diseases.
Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Allergy | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Prostaglandin Receptor
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